BCL-2 Antagonism to Target the Intrinsic Mitochondrial Pathway of Apoptosis
نویسندگان
چکیده
منابع مشابه
BCL-2 Antagonism to Target the Intrinsic Mitochondrial Pathway of Apoptosis.
Despite significant improvements in treatment, cure rates for many cancers remain suboptimal. The rise of cytotoxic chemotherapy has led to curative therapy for a subset of cancers, though intrinsic treatment resistance is difficult to predict for individual patients. The recent wave of molecularly targeted therapies has focused on druggable-activating mutations, and is thus limited to specific...
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Apoptosis is of great importance in various biological systems for functioning of physiological processes in multicellular organisms. It is also required for normal functioning of the body, embryonic development , tissue homeostasis , functioning of immune system , removal of defective cells. Various factors take part in the process of apoptosis , the critical control point being regulated by t...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2015
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-15-0364